GETTING PREPARED FOR THE SILVER WAVE: CHALLENGES IN CONDUCTING RHEUMATIC AND MUSCULOSKELETAL DISEASE RESEARCH IN OLDER ADULTS

Getting prepared for the silver wave: challenges in conducting rheumatic and musculoskeletal disease research in older adults

Research in older adults diagnosed with rheumatic and musculoskeletal diseases (RMDs) comes with unique challenges, as these patients often face consequences of ageing, such as multimorbidity, polypharmacy, and geriatric syndromes (eg, frailty).In this viewpoint, we highlight Enamel Pin various clinical, ethical, regulatory and logistical challenge

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Investigation of the Role of the TRPA1 Ion Channel in Conveying the Effect of Dimethyl Trisulfide on Vascular and Histological Changes in Serum-Transfer Arthritis

Rheumatoid arthritis (RA) is one of the most prevalent autoimmune diseases.Its therapy is often challenging, even in the era of biologicals.Previously, we observed the anti-inflammatory effects of garlic-derived organic polysulfide dimethyl trisulfide (DMTS).Some of these effects were mediated by activation of the TRPA1 ion channel.TRPA1 was mostly

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The use of whole-genome sequencing and development of bioinformatics to monitor overlapping outbreaks of Candida auris in southern Nevada

A Candida auris outbreak has been ongoing in Southern Nevada since August 2021.In this manuscript we describe the sequencing of over 200 C.auris isolates from patients at several facilities.Genetically distinct subgroups of C.auris were detected from Clade I (3 distinct Board Game Barbie lineages) and III (1 lineage).Open-source bioinformatic tools

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